aggravation aggravation /ˌægrəˈveɪʃən/

noun

1. Action that makes a problem or a disease (or its symptoms) worse  ( aggravation , exacerbation )
   action that makes a problem or a disease (or its symptoms) worse
    The aggravation of her condition resulted from lack of care
   the aggravation of her condition resulted from lack of care
   
2. Unfriendly behavior that causes anger or resentment  ( aggravation , irritation , provocation )
   unfriendly behavior that causes anger or resentment
   
3. An exasperated feeling of annoyance  ( aggravation , exasperation )
   an exasperated feeling of annoyance
     He let out a sigh of exasperation as his computer crashed for the third time.
   He let out a sigh of exasperation as his computer crashed for the third time.